| First Author | Wang F | Year | 2022 |
| Journal | Immunology | Volume | 165 |
| Issue | 1 | Pages | 88-98 |
| PubMed ID | 34435359 | Mgi Jnum | J:333855 |
| Mgi Id | MGI:7442354 | Doi | 10.1111/imm.13408 |
| Citation | Wang F, et al. (2022) LncRNA00492 is required for marginal zone B-cell development. Immunology 165(1):88-98 |
| abstractText | B-cell development undergoes a series of steps from the bone marrow to the secondary lymphoid organs. A defect in B-cell development can lead to immunodeficiency or malignant disorders, such as leukaemia or lymphoma. Long non-coding RNAs have been reported to act as important regulators of many pathological processes. However, very little is known regarding the role of lncRNAs during B-cell development and the regulation of their expression. In this study, we explored the expression and role of lncRNA Gme00492 in B-cell development. We observed that lnc00492 was highly expressed in B-cell development and primarily expressed in the nucleus. Lnc00492-deficient mice had fewer marginal zone B cells in the spleen, likely due to a developmental block. Importantly, lnc00492 interacts with CTBP1 and targets it for ubiquitination and degradation during B-cell development, whereas the transcriptional corepressor factor CTBP1 plays a critical role in Notch2 signalling. Thus, we identified a novel regulatory axis between lnc00492 and CTBP1 in B cells, suggesting that lnc00492 is essential for marginal zone B-cell development. |
