| Primary Identifier | MGI:3880720 | Allele Type | Gene trapped |
| Attribute String | Reporter | Gene | Akap13 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The beta-geo gene trap was inserted into intron 27. This mutation disrupts the protein kinase D (PKD)-binding domain of all three isoforms while the Rho-GEF domain remains intact. Quantitative PCR analysis of neonatal heart and lung RNA revealed that expression of the E37-38 exon-exon junction is reduced in a dose-dependent manner, while expression of the E4-5 exon-exon junction and the Brx-9 exon-exon junction remains unaffected. |
