| First Author | Kim YG | Year | 2021 |
| Journal | Mol Brain | Volume | 14 |
| Issue | 1 | Pages | 106 |
| PubMed ID | 34217333 | Mgi Jnum | J:320447 |
| Mgi Id | MGI:6726635 | Doi | 10.1186/s13041-021-00815-5 |
| Citation | Kim YG, et al. (2021) Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice. Mol Brain 14(1):106 |
| abstractText | Histone modifications are a key mechanism underlying the epigenetic regulation of gene expression, which is critically involved in the consolidation of multiple forms of memory. However, the roles of histone modifications in cerebellum-dependent motor learning and memory are not well understood. To test whether changes in histone methylation are involved in cerebellar learning, we used heterozygous Kdm3b knockout (Kdm3b(+/-)) mice, which show reduced lysine 9 on histone 3 (H3K9) demethylase activity. H3K9 di-methylation is significantly increased selectively in the granule cell layer of the cerebellum of Kdm3b(+/-) mice. In the cerebellum-dependent optokinetic response (OKR) learning, Kdm3b(+/-) mice show deficits in memory consolidation, whereas they are normal in basal oculomotor performance and OKR acquisition. In addition, RNA-seq analyses revealed that the expression levels of several plasticity-related genes were altered in the mutant cerebellum. Our study suggests that active regulation of histone methylation is critical for the consolidation of cerebellar motor memory. |
