| First Author | Ohs I | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 13708 | PubMed ID | 27982126 |
| Mgi Jnum | J:243453 | Mgi Id | MGI:5908506 |
| Doi | 10.1038/ncomms13708 | Citation | Ohs I, et al. (2016) Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis. Nat Commun 7:13708 |
| abstractText | Differentiation and homeostasis of natural killer (NK) cells relies on common gamma-chain (gammac)-dependent cytokines, in particular IL-15. Consequently, NK cells do not develop in mice with targeted gammac deletion. Herein we identify an alternative pathway of NK-cell development driven by the proinflammatory cytokine IL-12, which can occur independently of gammac-signalling. In response to viral infection or upon exogenous administration, IL-12 is sufficient to elicit the emergence of a population of CD122+CD49b+ cells by targeting NK-cell precursors (NKPs) in the bone marrow (BM). We confirm the NK-cell identity of these cells by transcriptome-wide analyses and their ability to eliminate tumour cells. Rather than using the conventional pathway of NK-cell development, IL-12-driven CD122+CD49b+ cells remain confined to a NK1.1lowNKp46low stage, but differentiate into NK1.1+NKp46+ cells in the presence of gammac-cytokines. Our data reveal an IL-12-driven hard-wired pathway of emergency NK-cell lymphopoiesis bypassing steady-state gammac-signalling. |
