| First Author | Simpson EM | Year | 1991 |
| Journal | Genomics | Volume | 11 |
| Issue | 3 | Pages | 601-8 |
| PubMed ID | 1774064 | Mgi Jnum | J:11581 |
| Mgi Id | MGI:59992 | Doi | 10.1016/0888-7543(91)90067-o |
| Citation | Simpson EM, et al. (1991) An interstitial deletion in mouse Y chromosomal DNA created a transcribed Zfy fusion gene. Genomics 11(3):601-8 |
| abstractText | The small portion of the mouse Y chromosome retained in the Sxra transposition is thought to carry at least five genes including, as demonstrated here, the entirety of the zinc-finger genes Zfy-1 and Zfy-2. Sxrb, a derivative of Sxra, was previously thought to retain Zfy-1 but to be deleted for Zfy-2. Here we show that Sxrb differs from Sxra as the result of unequal crossing-over between Zfy-1 and Zfy-2. This unequal crossing-over created a transcribed Zfy-2/1 fusion gene and an interstitial deletion. Our data and previous results together suggest that this deletion encompassed the 3' portion of Zfy-2, the histocompatibility gene Hya, the spermatogenesis factor Spy, and the 5' portion of Zfy-1. We suggest that not only Zfy but also other neighboring genes such as Spy and Hya may exist in two copies on the Y as the result of a large tandem duplication during rodent evolution. |
