Primary Identifier | MGI:5546196 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Casp8 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP site was inserted upstream of exon 3 and a floxed neo-tk cassette was inserted downstream of exon 4. The neo-tk cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Exons 3 and 4 were further removed by crossing with cre mice. |