| Primary Identifier | MGI:4093875 | Allele Type | Gene trapped |
| Attribute String | Null/knockout | Gene | Amfr |
| Transmission | Germline | Strain of Origin | C57BL/6N |
| Is Recombinase | false | Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: Nonalcoholic Steatohepatitis (NASH) J:221247. |
| molecularNote | Sequence tags for this gene trap insertion do not overlap a single known gene in the trapped gene orientation. It is possible that sequence tags for this gene trap overlap multiple genes in the trapped gene orientation, one or more genes in reverse orientation (not disrupted by the gene trap mechanism), or no known genes (using current gene model coordinates). J:221247 reports that the gene-trapping vector was inserted in the first intron downstream of the ATG codon between the first and second exons, which block production of endogenous transcription. RT-PCR and Western blot analysis confirmed absence of mRNA or protein in homozygous embryonic lysate or liver tissue. |
