| First Author | Hao H | Year | 2014 |
| Journal | Adv Exp Med Biol | Volume | 801 |
| Pages | 395-9 | PubMed ID | 24664723 |
| Mgi Jnum | J:252062 | Mgi Id | MGI:6107600 |
| Doi | 10.1007/978-1-4614-3209-8_50 | Citation | Hao H, et al. (2014) In vivo function of the ER-Golgi transport protein LMAN1 in photoreceptor homeostasis. Adv Exp Med Biol 801:395-9 |
| abstractText | LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in mouse retina. Therefore, we examined the in vivo function of LMAN1 in retina. Although Lman1 (- / -) mouse eyes did not show abnormality in histology and electroretinogram analysis at 3 months, Lman1 (- / -) retina at 6 months showed a decrease in cis-Golgi markers GM130 and GRASP65. We also observed abnormal level and location of Rhodopsin in these mice. Taken together, LMAN1 may play a role in photoreceptor gene transport and homeostasis. |
