| First Author | Fujimoto Y | Year | 2002 |
| Journal | Cell | Volume | 108 |
| Issue | 6 | Pages | 755-67 |
| PubMed ID | 11955430 | Mgi Jnum | J:75700 |
| Mgi Id | MGI:2177383 | Doi | 10.1016/s0092-8674(02)00673-6 |
| Citation | Fujimoto Y, et al. (2002) CD83 Expression Influences CD4(+) T Cell Development in the Thymus. Cell 108(6):755-67 |
| abstractText | T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4(+) T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83(-/-)) mice had a specific block in CD4(+) single-positive thymocyte development without increased CD4(+)CD8(+) double- or CD8(+) single-positive thymocytes. This resulted in a selective 75%-90% reduction in peripheral CD4(+) T cells, predominantly within the naive subset. Wild-type thymocytes and bone marrow stem cells failed to differentiate into mature CD4(+) T cells when transferred into CD83(-/-) mice, while CD83(-/-) thymocytes and stem cells developed normally in wild-type mice. Thereby, CD83 expression represents an additional regulatory component for CD4(+) T cell development in the thymus. |
