Primary Identifier | MGI:4126449 | Allele Type | Gene trapped |
Attribute String | Hypomorph, Reporter | Gene | Srgap2 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A gene trap vector inserted between exons 2 and 3 of the gene. Cortical cells from homozygous mice show a ~90% reduction in the level of expressed normal transcript and protein from this allele. The mutation results in the production of a fusion protein composed of the first 22 aa of SRGAP2 and beta-Geo. |