Primary Identifier | MGI:4126568 | Allele Type | Gene trapped |
Gene | Wtip | Transmission | Germline |
Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The insertion of a promoterless beta-geo casette in intron 2 results in splicing of exon 2 to beta-geo and production of a fusion transcript consisting of exons 1 and 2 with beta-geo. Western blot analysis demonstrated a reduction of protein abundance in glomerular lysates from heterozygous adult mice relative to wild-type controls. |