| First Author | Muñoz B | Year | 2020 |
| Journal | Addict Biol | Volume | 25 |
| Issue | 2 | Pages | e12726 |
| PubMed ID | 30884072 | Mgi Jnum | J:347389 |
| Mgi Id | MGI:7622082 | Doi | 10.1111/adb.12726 |
| Citation | Munoz B, et al. (2020) Influence of nonsynaptic alpha1 glycine receptors on ethanol consumption and place preference. Addict Biol 25(2):e12726 |
| abstractText | Here, we used knock-in (KI) mice that have ethanol-insensitive alpha 1 glycine receptors (GlyRs) (KK385/386AA) to examine how alpha 1 GlyRs might affect binge drinking and conditioned place preference. Data show that tonic alpha 1 GlyR-mediated currents were exclusively sensitive to ethanol only in wild-type mice. Behavioral studies showed that the KI mice have a higher intake of ethanol upon first exposure to drinking and greater conditioned place preference to ethanol. This study suggests that nonsynaptic alpha 1-containing GlyRs have a role in motivational and early reinforcing effects of ethanol. |
