| Primary Identifier | MGI:3819788 | Allele Type | Chemically induced (ENU) |
| Gene | Sox4 | Inheritance Mode | Dominant |
| Strain of Origin | B6.129S4-Insr<tm1Dac>/J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Male mice heterozygote for the Insrtm1Dac allele were treated with ENU and their offspring were screened for impaired glucose tolerance. One line derived from this screen was found to have a single A to G mutation at nucleotide position 1,025 of this gene locus. This corresponded to a tyrosine to cysteine substitution at amino acid 123 (Y123C), which lies in the highly conserved HMG-binding domain. Allelic complementation suggests that this is a functionally null allele. |
