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Allele : Tg(THY1-APP)1Somm transgene insertion 1, Bernd Sommer
Primary Identifier  MGI:2447144 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(THY1-APP)1Somm
Is Recombinase  false Is Wild Type  false
molecularNote  A human THY1 promoter and a human APP sequence carrying the Swedish double mutation K670M and N671L found in Alzheimer's disease patients was used for the transgene. In situ hybridization analysis of brain sections from transgenic animals showed the highest levels of transgene expression in the neocortex and hippocampus.
  • mutations:
  • Insertion
  • synonyms:
  • APP 14,
  • APP 14
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories

Trail: Allele




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