| Primary Identifier | MGI:2182322 | Allele Type | Transgenic |
| Attribute String | Hypomorph, Inserted expressed sequence | Gene | Gtf2ird1 |
| Strain of Origin | (C57BL/6 x CBA/J)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | Integration was mapped to a region on chromosome 5 that is orthologous to a human region hemizygously deleted in Williams-Beuren syndrome patients. |
| molecularNote | A transgene construct consisting of mouse Myc under the control of the mouse albumin promoter replaced of approximately 40 kb of chromosome 5, encompassing sequence downstream of Cyln2 through the first exon of Gtf2ird1. Northern blot and RT-PCR analysis of heart, muscle, liver, and spleen tissue from homozygous mutant mice showed highly reduced levels of Gtf2ird1 transcript. |
