| First Author | Arany Z | Year | 2007 |
| Journal | Cell Metab | Volume | 5 |
| Issue | 1 | Pages | 35-46 |
| PubMed ID | 17189205 | Mgi Jnum | J:118258 |
| Mgi Id | MGI:3699030 | Doi | 10.1016/j.cmet.2006.12.003 |
| Citation | Arany Z, et al. (2007) The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab 5(1):35-46 |
| abstractText | Skeletal muscle must perform different kinds of work, and distinct fiber types have evolved to accommodate these. Previous work had shown that the transcriptional coactivator PGC-1alpha drives the formation of type I and IIA muscle fibers, which are 'slow-twitch' and highly oxidative. We show here that transgenic expression of PGC-1beta, a coactivator functionally similar to but distinct from PGC-1alpha, causes a marked induction of IIX fibers, which are oxidative but have 'fast-twitch' biophysical properties. PGC-1beta coactivates the MEF2 family of transcription factors to stimulate the type IIX myosin heavy chain (MHC) promoter. PGC-1beta transgenic muscle fibers are rich in mitochondria and are highly oxidative, at least in part due to coactivation by PGC-1beta of ERRalpha and PPARalpha. Consequently, these transgenic animals can run for longer and at higher work loads than wild-type animals. Together, these data indicate that PGC-1beta drives the formation of highly oxidative fibers containing type IIX MHC. |
