| First Author | Rowe GC | Year | 2011 |
| Journal | Am J Physiol Endocrinol Metab | Volume | 301 |
| Issue | 1 | Pages | E155-63 |
| PubMed ID | 21364124 | Mgi Jnum | J:182079 |
| Mgi Id | MGI:5314691 | Doi | 10.1152/ajpendo.00681.2010 |
| Citation | Rowe GC, et al. (2011) PGC-1beta regulates angiogenesis in skeletal muscle. Am J Physiol Endocrinol Metab 301(1):E155-63 |
| abstractText | Aerobic metabolism requires oxygen and carbon sources brought to tissues via the vasculature. Metabolically active tissues such as skeletal muscle can regulate blood vessel density to match metabolic needs; however, the molecular cues that coordinate these processes remain poorly understood. Here we report that the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1beta (PGC-1beta), a potent regulator of mitochondrial biology, induces angiogenesis in skeletal muscle. PGC-1beta induces the expression of vascular endothelial growth factor (VEGF) in cell culture and in vivo. The induction of VEGF by PGC-1beta requires coactivation of the orphan nuclear receptor estrogen-related receptor-alpha (ERRalpha) and is independent of the hypoxia-inducible factor (HIF) pathway. In coculture experiments, overexpression of PGC-1beta in skeletal myotubes increases the migration of adjacent endothelial cells, and this depends on VEGF signaling. Transgenic expression of PGC-1beta in skeletal myocytes dramatically increases muscular vessel density. Taken together, these data indicate that PGC-1beta is a potent regulator of angiogenesis, thus providing a novel link between the regulations of oxidative metabolism and vascular density. |
