| First Author | Giralt A | Year | 2020 |
| Journal | Exp Neurol | Volume | 323 |
| Pages | 113095 | PubMed ID | 31712124 |
| Mgi Jnum | J:283039 | Mgi Id | MGI:6381908 |
| Doi | 10.1016/j.expneurol.2019.113095 | Citation | Giralt A, et al. (2020) Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation. Exp Neurol 323:113095 |
| abstractText | Currently, molecular, electrophysiological and structural studies delineate several neural subtypes in the hippocampus. However, the precise developmental mechanisms that lead to this diversity are still unknown. Here we show that alterations in a concrete hippocampal neuronal subpopulation during development specifically affect hippocampal-dependent spatial memory. We observed that the genetic deletion of the transcription factor Helios in mice, which is specifically expressed in developing hippocampal calbindin-positive CA1 pyramidal neurons (CB-CA1-PNs), induces adult alterations affecting spatial memory. In the same mice, CA3-CA1 synaptic plasticity and spine density and morphology in adult CB-CA1-PNs were severely compromised. RNAseq experiments in developing hippocampus identified an aberrant increase on the Visinin-like protein 1 (VSNL1) expression in the hippocampi devoid of Helios. This aberrant increase on VSNL1 levels was localized in the CB-CA1-PNs. Normalization of VSNL1 levels in CB-CA1-PNs devoid of Helios rescued their spine loss in vitro. Our study identifies a novel and specific developmental molecular pathway involved in the maturation and function of a CA1 pyramidal neuronal subtype. |
