| First Author | Lattke M | Year | 2012 |
| Journal | J Neurosci | Volume | 32 |
| Issue | 34 | Pages | 11511-23 |
| PubMed ID | 22915098 | Mgi Jnum | J:187707 |
| Mgi Id | MGI:5437808 | Doi | 10.1523/JNEUROSCI.0182-12.2012 |
| Citation | Lattke M, et al. (2012) Nuclear Factor kappaB Activation Impairs Ependymal Ciliogenesis and Links Neuroinflammation to Hydrocephalus Formation. J Neurosci 32(34):11511-23 |
| abstractText | Hydrocephalus formation is a frequent complication of neuropathological insults associated with neuroinflammation. However, the mechanistic role of neuroinflammation in hydrocephalus development is unclear. We have investigated the function of the proinflammatory acting inhibitor of kappaB kinase (IKK)/nuclear factor kappaB (NF-kappaB) signaling system in neuroinflammatory processes and generated a novel mouse model that allows conditional activation of the IKK/NF-kappaB system in astrocytes. Remarkably, NF-kappaB activation in astrocytes during early postnatal life results in hydrocephalus formation and additional defects in brain development. NF-kappaB activation causes global neuroinflammation characterized by a strong, astrocyte-specific expression of proinflammatory NF-kappaB target genes as well as a massive infiltration and activation of macrophages. In this animal model, hydrocephalus formation is specifically induced during a critical time period of early postnatal development, in which IKK/NF-kappaB-induced neuroinflammation interferes with ependymal ciliogenesis. Our findings demonstrate for the first time that IKK/NF-kappaB activation is sufficient to induce hydrocephalus formation and provides a potential mechanistic explanation for the frequent association of neuroinflammation and hydrocephalus formation during brain development, namely impairment of ependymal cilia formation. Therefore, our study might open up new perspectives for the treatment of certain types of neonatal and childhood hydrocephalus associated with hemorrhages and infections. |
