| First Author | Saw J | Year | 2013 |
| Journal | Leuk Res | Volume | 37 |
| Issue | 12 | Pages | 1668-73 |
| PubMed ID | 24090997 | Mgi Jnum | J:320505 |
| Mgi Id | MGI:6872798 | Doi | 10.1016/j.leukres.2013.09.013 |
| Citation | Saw J, et al. (2013) The fusion partner specifies the oncogenic potential of NUP98 fusion proteins. Leuk Res 37(12):1668-73 |
| abstractText | NUP98 is among the most promiscuously translocated genes in hematological diseases. Among the 28 known fusion partners, there are two categories: homeobox genes and non-homeobox genes. The homeobox fusion partners are well-studied in animal models, resulting in HoxA cluster overexpression and hematological disease. The non-homeobox fusion partners are less well studied. We created transgenic animal models for three NUP98 fusion genes (one homeobox, two non-homeobox), and show that in this system, the NUP98-homeobox fusion promotes self-renewal and aberrant gene expression to a significantly greater extent. We conclude that homeobox partners create more potent NUP98 fusion oncogenes than do non-homeobox partners. |
