| First Author | Harach T | Year | 2012 |
| Journal | Sci Rep | Volume | 2 |
| Pages | 430 | PubMed ID | 22666533 |
| Mgi Jnum | J:207273 | Mgi Id | MGI:5555005 |
| Doi | 10.1038/srep00430 | Citation | Harach T, et al. (2012) TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Sci Rep 2:430 |
| abstractText | Anionic exchange resins are bona fide cholesterol-lowering agents with glycemia lowering actions in diabetic patients. Potentiation of intestinal GLP-1 secretion has been proposed to contribute to the glycemia lowering effect of these non-systemic drugs. Here, we show that resin exposure enhances GLP-1 secretion and improves glycemic control in diet-induced animal models of "diabesity", effects which are critically dependent on TGR5, a G protein-coupled receptor that is activated by bile acids. We identified the colon as a major source of GLP-1 secretion after resin treatment. Furthermore, we demonstrate that the boost in GLP-1 release by resins is due to both enhanced TGR5-dependent production of the precursor transcript of GLP-1 as well as to the local enrichment of TGR5 agonists in the colon. Thus, TGR5 represents an essential component in the pathway mediating the enhanced GLP-1 release in response to anionic exchange resins. |
