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Allele : Esr1<tm2.1Gsc> estrogen receptor 1 (alpha); targeted mutation 2.1, Gunther Schutz
Primary Identifier  MGI:4361324 Allele Type  Targeted
Gene  Esr1 Transmission  Germline
Strain of Origin  129P2/OlaHsd Is Recombinase  false
Is Wild Type  false
molecularNote  Nucleotide substitutions resulted in amino acid substitutions of glutamic acid for tyrosine at position 201 (Y201E), alanine for lysine at position 210 (K210A), alanine for lysine at position 214 (K214A), and glutamic acid for arginine at position 215 (R215E). A floxed neo cassette used for selection was removed by transient cre expression in ES cells. The mutated amino acids are a part of the DNA recognition helix.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • ERalpha<EAAE>,
  • ERalpha<EAAE>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

7 Publication categories

Trail: Allele




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