| First Author | Isett BR | Year | 2023 |
| Journal | Neuron | Volume | 111 |
| Issue | 14 | Pages | 2218-2231.e4 |
| PubMed ID | 37207651 | Mgi Jnum | J:337746 |
| Mgi Id | MGI:7506166 | Doi | 10.1016/j.neuron.2023.04.017 |
| Citation | Isett BR, et al. (2023) The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression. Neuron |
| abstractText | Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-SPNs) in the striatum drives locomotor suppression and transient punishment, results attributed to activation of the indirect pathway. The sole long-range projection target of A2A-SPNs is the external globus pallidus (GPe). Unexpectedly, we found that inhibition of the GPe drove transient punishment but not suppression of movement. Within the striatum, A2A-SPNs inhibit other SPNs through a short-range inhibitory collateral network, and we found that optogenetic stimuli that drove motor suppression shared a common mechanism of recruiting this inhibitory collateral network. Our results suggest that the indirect pathway plays a more prominent role in transient punishment than in motor control and challenges the assumption that activity of A2A-SPNs is synonymous with indirect pathway activity. |
