| First Author | Gallardo M | Year | 2015 |
| Journal | Cancer Cell | Volume | 28 |
| Issue | 4 | Pages | 486-499 |
| PubMed ID | 26412324 | Mgi Jnum | J:225947 |
| Mgi Id | MGI:5695377 | Doi | 10.1016/j.ccell.2015.09.001 |
| Citation | Gallardo M, et al. (2015) hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies. Cancer Cell 28(4):486-99 |
| abstractText | hnRNP K regulates cellular programs, and changes in its expression and mutational status have been implicated in neoplastic malignancies. To directly examine its role in tumorigenesis, we generated a mouse model harboring an Hnrnpk knockout allele (Hnrnpk(+/-)). Hnrnpk haploinsufficiency resulted in reduced survival, increased tumor formation, genomic instability, and the development of transplantable hematopoietic neoplasms with myeloproliferation. Reduced hnRNP K expression attenuated p21 activation, downregulated C/EBP levels, and activated STAT3 signaling. Additionally, analysis of samples from primary acute myeloid leukemia patients harboring a partial deletion of chromosome 9 revealed a significant decrease in HNRNPK expression. Together, these data implicate hnRNP K in the development of hematological disorders and suggest hnRNP K acts as a tumor suppressor. |
