| First Author | Lv YP | Year | 2019 |
| Journal | Sci Adv | Volume | 5 |
| Issue | 4 | Pages | eaau6547 |
| PubMed ID | 30949574 | Mgi Jnum | J:287580 |
| Mgi Id | MGI:6415449 | Doi | 10.1126/sciadv.aau6547 |
| Citation | Lv YP, et al. (2019) Helicobacter pylori-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis. Sci Adv 5(4):eaau6547 |
| abstractText | The interaction between gastric epithelium and immune response plays key roles in H. pylori-associated pathology. We demonstrated a procolonization and proinflammation role of MMP-10 in H. pylori infection. MMP-10 is elevated in gastric mucosa and is produced by gastric epithelial cells synergistically induced by H. pylori and IL-22 via the ERK pathway. Human gastric MMP-10 was correlated with H. pylori colonization and the severity of gastritis, and mouse MMP-10 from non-BM-derived cells promoted bacteria colonization and inflammation. H. pylori colonization and inflammation were attenuated in IL-22(-/-), MMP-10(-/-), and IL-22(-/-)MMP-10(-/-) mice. MMP-10-associated inflammation is characterized by the influx of CD8(+) T cells, whose migration is induced via MMP-10-CXCL16 axis by gastric epithelial cells. Under the influence of MMP-10, Reg3a, E-cadherin, and zonula occludens-1 proteins decrease, resulting in impaired host defense and increased H. pylori colonization. Our results suggest that MMP-10 facilitates H. pylori persistence and promotes gastritis. |
