| First Author | Doron G | Year | 2020 |
| Journal | Science | Volume | 370 |
| Issue | 6523 | PubMed ID | 33335033 |
| Mgi Jnum | J:299275 | Mgi Id | MGI:6488681 |
| Doi | 10.1126/science.aaz3136 | Citation | Doron G, et al. (2020) Perirhinal input to neocortical layer 1 controls learning. Science 370(6523) |
| abstractText | Hippocampal output influences memory formation in the neocortex, but this process is poorly understood because the precise anatomical location and the underlying cellular mechanisms remain elusive. Here, we show that perirhinal input, predominantly to sensory cortical layer 1 (L1), controls hippocampal-dependent associative learning in rodents. This process was marked by the emergence of distinct firing responses in defined subpopulations of layer 5 (L5) pyramidal neurons whose tuft dendrites receive perirhinal inputs in L1. Learning correlated with burst firing and the enhancement of dendritic excitability, and it was suppressed by disruption of dendritic activity. Furthermore, bursts, but not regular spike trains, were sufficient to retrieve learned behavior. We conclude that hippocampal information arriving at L5 tuft dendrites in neocortical L1 mediates memory formation in the neocortex. |
