Primary Identifier | MGI:4374347 | Allele Type | Gene trapped |
Attribute String | Conditional ready, Null/knockout | Gene | Nipbl |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A conditional-ready gene trap cassette with FRT, F3, loxP, and Lox5171 sites upstream of a beta-geo reporter followed downstream by loxP, lox5171, FRT, and F3 sites in inverse orientation, was inserted into exon 1. This insertion is in the original gene-trapped configuration so that transcription is stopped at the beta-geo reporter, yielding a null allele, which can be excised into a functional allele through Flp- or Cre-mediated excision. |