| First Author | Ghaedi M | Year | 2016 |
| Journal | Cell Rep | Volume | 15 |
| Issue | 3 | Pages | 471-480 |
| PubMed ID | 27068476 | Mgi Jnum | J:235178 |
| Mgi Id | MGI:5793019 | Doi | 10.1016/j.celrep.2016.03.039 |
| Citation | Ghaedi M, et al. (2016) Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development. Cell Rep 15(3):471-80 |
| abstractText | All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s). Here, we have divided LMPPs into CD127(-) (LMPP-s) and CD127(+) (LMPP+s) subsets and compared them with Ly6D(-) and Ly6D(+) CLPs. Adult LMPP+s differentiated into T cells and ILCs more rapidly and efficiently than other progenitors in transplantation assays. The development of T cells and ILC2s is highly active in the neonatal period. Neonatal CLPs are rare and, unlike prominent neonatal LMPP+s, do not efficiently differentiate into T cells and ILC2s. ILC2s generated in the neonatal period are long lived and persist in adult tissues. These results suggest that some ILCs and T cells may develop from LMPP+s via CLP-independent pathways. |
