| First Author | Zhang J | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 19 | Pages | 3255-62 |
| PubMed ID | 22771905 | Mgi Jnum | J:188544 |
| Mgi Id | MGI:5440827 | Doi | 10.1016/j.febslet.2012.06.047 |
| Citation | Zhang J, et al. (2012) Interferon-beta-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF. FEBS Lett 586(19):3255-62 |
| abstractText | IFN-beta is induced via a c-fos dependent mechanism that is present downstream of the receptor activator of NF-kappaB ligand (RANKL)-RANK signal transduction cascade during osteoclast differentiation. Increased production of IFN-beta in turn inhibits osteoclastogenesis. However, the mechanism by which IFN-beta exerts its suppressive function remains unclear. In the present study, we found that miR-155, an IFN-beta-induced miRNA, mediated the suppressive effect of IFN-beta on osteoclast differentiation by targeting SOCS1 and MITF, two essential regulators of osteoclastogenesis. These findings have not only demonstrated that miR-155 inhibits osteoclast differentiation, but also provided a new therapeutic target for treatment of osteoclast-mediated diseases. |
