| Primary Identifier | MGI:4411997 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(HBB-AR-HBA2,-HBB*)58Rub |
| Strain of Origin | Swiss Webster | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The 800 bp DNA fragment containing the hypersensitive II region of the human HBB locus control region was used to drive erythroid-specific expression of human HBA2 and human HBB containing the Sickle Antilles mutations (G6V and V23I) in co-injected constructs. Two founders were generated (14 and 58). The line from founder 58 contains 4 copies of the HBA2 expressing construct and 10 copies of the HBB* expressing construct. |
