| Primary Identifier | MGI:4412181 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(FXN)YG22Pook |
| Strain of Origin | CBA x C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| description | Line YG22 exhibits slightly greater age-related repeat instability than line YG8, with a bias toward repeat expansion. |
| molecularNote | The transgenic construct consists of a 370kb YAC insert that includes the entire human FXN gene with GAA triplet repeat sequences, and was injected into fertilized CBA X C57BL/6 hybrid fertilized oocytes. Founder line YG22 was generated, showing a reduced transmission rate of 21%, indicating germ-line mosaicism of the transgene, compared to 52% transmission to offspring for founder line YG8. One copy of the FXN gene was detected, and contains a single 190 GAA repeat sequence. |
