| First Author | Goto J | Year | 2006 |
| Journal | Neurosci Res | Volume | 55 |
| Issue | 1 | Pages | 28-33 |
| PubMed ID | 16472880 | Mgi Jnum | J:112757 |
| Mgi Id | MGI:3663528 | Doi | 10.1016/j.neures.2006.01.001 |
| Citation | Goto J, et al. (2006) Short-term potentiation at the parallel fiber-Purkinje cell synapse. Neurosci Res 55(1):28-33 |
| abstractText | Changes in synaptic efficacy at the parallel fiber (PF)-Purkinje cell (PC) synapse are postulated to be a cellular basis for motor learning. Although long-term efficacy changes lasting more than an hour at this synapse, i.e., long-term potentiation and depression, have been extensively studied, relatively short lasting synaptic efficacy changes, namely short-term potentiation (STP) lasting for tens of minutes, have not been discussed to date. Here we report that this synapse shows an apparent STP reliably by a periodic burst pattern of homosynaptic stimulation. This STP is presynaptically expressed, since it accompanies with a reduced paired-pulse facilitation and is resistant to postsynaptic Ca(2+) reduction by BAPTA injection or in P/Q-type Ca channel knockout cerebella. This novel type of synaptic plasticity at the PF-PC synapse would be a clue for understanding the presynaptic mechanisms of plasticity at this synapse. |
