| First Author | Wong AB | Year | 2019 |
| Journal | Elife | Volume | 8 |
| PubMed ID | 31612853 | Mgi Jnum | J:284521 |
| Mgi Id | MGI:6382249 | Doi | 10.7554/eLife.49091 |
| Citation | Wong AB, et al. (2019) Tonotopic and non-auditory organization of the mouse dorsal inferior colliculus revealed by two-photon imaging. Elife 8:e49091 |
| abstractText | The dorsal (DCIC) and lateral cortices (LCIC) of the inferior colliculus are major targets of the auditory and non-auditory cortical areas, suggesting a role in complex multimodal information processing. However, relatively little is known about their functional organization. We utilized in vivo two-photon Ca(2+) imaging in awake mice expressing GCaMP6s in GABAergic or non-GABAergic neurons in the IC to investigate their spatial organization. We found different classes of temporal responses, which we confirmed with simultaneous juxtacellular electrophysiology. Both GABAergic and non-GABAergic neurons showed spatial microheterogeneity in their temporal responses. In contrast, a robust, double rostromedial-caudolateral gradient of frequency tuning was conserved between the two groups, and even among the subclasses. This, together with the existence of a subset of neurons sensitive to spontaneous movements, provides functional evidence for redefining the border between DCIC and LCIC. |
