| First Author | Chambers AR | Year | 2022 |
| Journal | Cell Rep | Volume | 40 |
| Issue | 4 | Pages | 111132 |
| PubMed ID | 35905724 | Mgi Jnum | J:354705 |
| Mgi Id | MGI:7329685 | Doi | DOI:10.1016/j.celrep.2022.111132 |
| Citation | Chambers AR, et al. (2022) Cell-type-specific silence in thalamocortical circuits precedes hippocampal sharp-wave ripples. Cell Rep 40(4):111132 |
| abstractText | Evidence suggests that the hippocampus conveys memory-related neural patterns across distributed cortical circuits during high-frequency oscillations called sharp-wave ripples (SWRs). We investigate how circuit activity in the retrosplenial cortex (RSC), a primary hippocampal target, could aid in processing SWR-related input. Using patch-clamp recordings from awake mice, we find that SWR-aligned membrane potential modulation is widespread but weak, and that spiking responses are sparse. However, using cell-type-specific two-photon Ca(2+) imaging and optogenetics, we show that, 1-2 s before SWRs, superficial inhibition and thalamocortical input in RSC is reduced. We propose that pyramidal dendrites experience decreased local inhibition and subcortical interference in a seconds-long time window preceding SWRs. This may aid communication of weak and sparse SWR-aligned excitation between the hippocampus and neocortex and promote the strengthening of memory-related connections. |
