| First Author | Su T | Year | 2015 |
| Journal | Elife | Volume | 4 |
| PubMed ID | 25667983 | Mgi Jnum | J:220179 |
| Mgi Id | MGI:5632434 | Doi | 10.7554/eLife.02948 |
| Citation | Su T, et al. (2015) Two-signal requirement for growth-promoting function of Yap in hepatocytes. Elife 4 |
| abstractText | The transcriptional coactivator Yes-associated protein (Yap) promotes proliferation and inhibits apoptosis, suggesting that Yap functions as an oncogene. Most oncogenes, however, require a combination of at least two signals to promote proliferation. In this study, we present evidence that Yap activation is insufficient to promote growth in the otherwise normal tissue. Using a mosaic mouse model, we demonstrate that Yap overexpression in a fraction of hepatocytes does not lead to their clonal expansion, as proliferation is counterbalanced by increased apoptosis. To shift the activity of Yap towards growth, a second signal provided by tissue damage or inflammation is required. In response to liver injury, Yap drives clonal expansion, suppresses hepatocyte differentiation, and promotes a progenitor phenotype. These results suggest that Yap activation is insufficient to promote growth in the absence of a second signal thus coordinating tissue homeostasis and repair. |
