Primary Identifier | MGI:4430234 | Allele Type | Targeted |
Attribute String | Modified regulatory region, Null/knockout, Reporter | Gene | Foxp3 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Two loxP sequences flanking conserved non-coding sequence 3 (CNS3 (Rr131)), within intron 3 downstream of the 1st coding exon, as well as an FRT site flanked neomycin resistance gene cassette were inserted by homologous recombination. In addition, an EGFP cassette was inserted in-frame into the first coding exon. The selection cassette and the CNS were removed by flp- and cre-mediated recombination. |