| Primary Identifier | MGI:4430086 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Rho-GUCA1A*Y99C)L53Amd |
| Strain of Origin | C57BL/6 x DBA/2 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The mouse promoter drives rod and cone-specific expression of the bovine cDNA containing a mutation that results in an amino acid substitution of cysteine for tyrosine at position 99 (Y99C). This mutation is found in human patients with late-onset retinal dystrophy. Several lines were created (L52, L52H, L53, L36, L39, L128, and L52X). Line L53 exhibit a 3- to 4-fold in expression compared to endogenous levels. |
