| First Author | Yang J | Year | 2022 |
| Journal | Stem Cells | Volume | 40 |
| Issue | 1 | Pages | 74-87 |
| PubMed ID | 35511870 | Mgi Jnum | J:355085 |
| Mgi Id | MGI:7643661 | Doi | 10.1093/stmcls/sxab010 |
| Citation | Yang J, et al. (2022) Mst1/2 Is Necessary for Satellite Cell Differentiation to Promote Muscle Regeneration. Stem Cells 40(1):74-87 |
| abstractText | The diminished ability for muscle to regenerate is associated with aging, diabetes, and cancers. Muscle regeneration depends on the activation and differentiation of satellite cells (SCs). Inactivation of Mst1/2 promotes cell proliferation by activating Yap, and that has been reported as a potential therapeutic target for improving many organ regeneration. However, the function of Mst1/2 in SCs fate decision and that effect on muscle regeneration remain unknown. By using inducible conditional knockout Mst1/2 in the SCs of mice and an inhibitor of Mst1/2, we found that inhibition of Mst1/2 in SCs significantly decrease Yap phosphorylation, thus causing Yap to accumulate in the nucleus and impairing SC differentiation; Mst1/2 were slightly elevated by irisin stimulation during SC differentiation; but inhibiting Mst1/2 in SCs significantly impaired irisin-induced muscle regeneration. These results indicate that Mst1/2 is necessary for SC differentiation and inhibiting Mst1/2 as a therapeutic target has potential risks for muscle regeneration. |
