| First Author | Yin TC | Year | 2020 |
| Journal | iScience | Volume | 23 |
| Issue | 6 | Pages | 101216 |
| PubMed ID | 32535024 | Mgi Jnum | J:306812 |
| Mgi Id | MGI:6718059 | Doi | 10.1016/j.isci.2020.101216 |
| Citation | Yin TC, et al. (2020) The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in delta Cells. iScience 23(6):101216 |
| abstractText | Ghrelin regulates both energy intake and glucose homeostasis. In the endocrine pancreas, ghrelin inhibits insulin release to prevent hypoglycemia during fasting. The mechanism through which this is accomplished is unclear, but recent studies suggest that ghrelin acts on delta cells to stimulate somatostatin release, which in turn inhibits insulin release from beta cells. Recently, the Melanocortin Receptor Accessory Protein 2 (MRAP2) was identified as an essential partner of the ghrelin receptor (GHSR1a) in mediating the central orexigenic action of ghrelin. In this study we show that MRAP2 is expressed in islet delta cells and is required for ghrelin to elicit a calcium response in those cells. Additionally, we show that both global and delta cell targeted deletion of MRAP2 abrogates the insulinostatic effect of ghrelin. Together, these findings establish that ghrelin signaling within delta cells is essential for the inhibition of insulin release and identify MRAP2 as a regulator of insulin secretion. |
