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Allele : Runx1<tm1.1Gss> runt related transcription factor 1; targeted mutation 1.1, Gary S Stein
Primary Identifier  MGI:4437264 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Runx1
Transmission  Germline Strain of Origin  129S4/SvJae-Tg(Prm-cre)70Og
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 8 was replaced with a floxed neo cassette and a modified exon 8 that contains a C to T transition producing a termination codon instead of glutamine at position 307 (Q307X), modeling genetic lesions observed in patients with leukemia and myeloproliferative disorders. Cre-mediated excision driven by the Tg(Prm-cre)70Og transgene carried by the parental PC3 ES cells removed the neo cassette upon transmission from male chimeras.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • Runx1<Q307X>,
  • Runx1<Q307X>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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