| First Author | Han L | Year | 2018 |
| Journal | Nat Neurosci | Volume | 21 |
| Issue | 3 | Pages | 324-328 |
| PubMed ID | 29403029 | Mgi Jnum | J:262401 |
| Mgi Id | MGI:6158717 | Doi | 10.1038/s41593-018-0074-8 |
| Citation | Han L, et al. (2018) Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness. Nat Neurosci 21(3):324-328 |
| abstractText | Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma. |
