Primary Identifier | MGI:4436910 | Allele Type | Targeted |
Attribute String | Humanized sequence, Modified isoform(s) | Gene | Vhl |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A guanine to adenine transition at base 518 in exon 3 causes a change in codon 167 with the replacement of arginine by glutamine (R518Q) in the resulting protein. A floxed neomycin cassette was inserted in intron 2 as well. Transient transfection with a cre expressing vector resulted in excision of the neomycin selection cassette. |