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Allele : Vhl<tm1.1Wkr> von Hippel-Lindau tumor suppressor; targeted mutation 1.1, WK Rathmell

Primary Identifier  MGI:4436910 Allele Type  Targeted
Attribute String  Humanized sequence, Modified isoform(s) Gene  Vhl
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  A guanine to adenine transition at base 518 in exon 3 causes a change in codon 167 with the replacement of arginine by glutamine (R518Q) in the resulting protein. A floxed neomycin cassette was inserted in intron 2 as well. Transient transfection with a cre expressing vector resulted in excision of the neomycin selection cassette.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Vhl<2B>,
  • Vhl<2B>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

5 Publication categories

Trail: Allele