| Primary Identifier | MGI:4438229 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(HTT*)BXwy |
| Strain of Origin | FVB | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The 240 kb human bacterial artificial chromosome BAC(RP11-866L6), containing the entire 170 kb human Huntingtin (htt) genomic locus and approximately 20 kbp of 5' and 50 kbp of 3' flanking sequences, was modified by replacing the human htt exon 1 with a loxP-flanked human mutant htt exon 1 sequence (containing 97 mixed CAA-CAG repeats encoding a continuous polyglutamine (polyQ) stretch). Nucleotide substitution resulted in amino acid substitution of aspartic acid for serine at positions 13 and 16. Two lines were created (line B and C). |
