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Allele : Tg(ACTB-APP*V717F)1Colm transgene insertion 1, Colin L Masters

Primary Identifier  MGI:4438112 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(ACTB-APP*V717F)1Colm
Strain of Origin  (C57BL/6 x DBA)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  The human promoter was used to drive ubiquitous expression of the C-terminal portion of human APP (C100) with an amino acid substitution of phenyalanine for valine at position 717 (V717F), also known as the London mutation. One line was created (no line number given) with 40 to 50 copies of the transgene.
  • mutations:
  • Insertion
  • synonyms:
  • TgC100.V717F,
  • Tg C100.V717F,
  • TgC100.V717F,
  • APPC100.V717F,
  • Tg C100.V717F,
  • APPC100.V717F
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele