| First Author | Sasaki H | Year | 1986 |
| Journal | Biochem Biophys Res Commun | Volume | 139 |
| Issue | 2 | Pages | 794-9 |
| PubMed ID | 3021142 | Mgi Jnum | J:159166 |
| Mgi Id | MGI:4441473 | Doi | 10.1016/s0006-291x(86)80060-2 |
| Citation | Sasaki H, et al. (1986) Generation of transgenic mice producing a human transthyretin variant: a possible mouse model for familial amyloidotic polyneuropathy. Biochem Biophys Res Commun 139(2):794-9 |
| abstractText | Type I familial amyloidotic polyneuropathy (FAP) results from the systemic deposition of a plasma transthyretin (TTR) variant with a Val----Met change at position 30. In an attempt to establish a model of this disease, we generated transgenic mice producing the variant TTR. A DNA fragment containing the mouse metallothionein-I promoter fused to the structural gene coding for the human TTR variant was microinjected into fertilized mouse eggs. Among 72 mice that developed from these eggs, ten carried the fusion gene and three of these showed significant concentrations of the variant TTR in their serum. These mice may be useful in elucidating the pathogenesis of FAP and in establishing a therapy for this intractable disorder. |
