| First Author | Kang BN | Year | 2010 |
| Journal | J Neurosci | Volume | 30 |
| Issue | 1 | Pages | 93-8 |
| PubMed ID | 20053891 | Mgi Jnum | J:157643 |
| Mgi Id | MGI:4431305 | Doi | 10.1523/JNEUROSCI.3974-09.2010 |
| Citation | Kang BN, et al. (2010) Death-associated protein kinase-mediated cell death modulated by interaction with DANGER. J Neurosci 30(1):93-8 |
| abstractText | Death-associated protein kinase (DAPK) is a key player in multiple cell death signaling pathways. We report that DAPK is regulated by DANGER, a partial MAB-21 domain-containing protein. DANGER binds directly to DAPK and inhibits DAPK catalytic activity. DANGER-deficient mouse embryonic fibroblasts and neurons exhibit greater DAPK activity and increased sensitivity to cell death stimuli than do wild-type control cells. In addition, DANGER-deficient mice manifest more severe brain damage after acute excitotoxicity and transient cerebral ischemia than do control mice. Accordingly, DANGER may physiologically regulate the viability of neurons and represent a potential therapeutic target for stroke and neurodegenerative diseases. |
