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Transgene : Tg(Lhb-TAg)#Plm transgene insertion, Pamela L Mellon
Primary Identifier  MGI:98721 Organism  mouse, laboratory
Chromosome  4 Mgi Type  transgene
description  PHENOTYPE: Expression of simian virus 40 T antigen as a transgene in retina produces ocular tumors similar to human retinoblastoma. The SV40 T antigen associates with and inactivates Rb1 gene product, resulting in a functional deficiency resembling that in mice with null mutations for Rb1. [provided by MGI curators]
  • synonyms:
  • Tg(Lhb-TAg)#Plm,
  • Tag-Rb,
  • SV40 T antigen transgene (retinoblastoma),
  • transgene insertion, Pamela L Mellon,
  • Tg.Rb,
  • MGD-MRK-14706,
  • SV40 T antigene transgen (retinoblastoma),
  • MGD-MRK-15059
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