| First Author | Sakano T | Year | 2022 |
| Journal | Biosci Biotechnol Biochem | Volume | 86 |
| Issue | 9 | Pages | 1276-1285 |
| PubMed ID | 35641020 | Mgi Jnum | J:339123 |
| Mgi Id | MGI:7519282 | Doi | 10.1093/bbb/zbac081 |
| Citation | Sakano T, et al. (2022) Pharmacokinetics and tissue distribution of orally administrated imidazole dipeptides in carnosine synthase gene knockout mice. Biosci Biotechnol Biochem 86(9):1276-1285 |
| abstractText | Imidazole dipeptides (ID) are abundant in skeletal muscle and the brain and have various functions, such as antioxidant, pH-buffering, metal-ion chelation. However, the physiological significance of ID has not been fully elucidated. In this study, we orally administered ID to conventional carnosine synthase gene-deficient mice (Carns-KO mice) to investigate the pharmacokinetics. Carnosine or anserine was administered at a dose of 500 mg ( approximately 2 mmol) per kilogram of mouse body weight, and ID contents in the tissues were measured. No ID were detected in untreated Carns-KO mice. In the ID treatment groups, the ID concentrations in the tissues increased in a time-dependent manner in the gastrocnemius muscle, soleus muscle, and cerebrum after ID administration. Our findings suggest that the Carns-KO mice are a valuable animal model for directly evaluating the effects of dietary ID and for elucidating the physiological functions of oral ID administration. |
