Primary Identifier | MGI:4453222 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Lrp5 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Alanine 213 of the targeted gene was converted to valine (A213V) (equivalent to the human A214V missense mutation) via site-directed mutagenesis. Cre mediated recombination removed the floxed neo cassette inserted into intron 2. |