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Publication : Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9.

First Author  Peters J Year  1981
Journal  Biochem Genet Volume  19
Issue  7-8 Pages  757-69
PubMed ID  7295297 Mgi Jnum  J:6625
Mgi Id  MGI:55100 Doi  10.1007/BF00484007
Citation  Peters J, et al. (1981) Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9. Biochem Genet 19(7-8):757-69
abstractText  An electrophoretically detectable variant of pyruvate kinase (EC 2.7.1.40) has been found in the house mouse Mus musculus. The variant was seen in all tissues examined except liver and red cells. The gene (Pk-3) determining this electrophoretic variation is inherited as an autosomal codominant located on chromosome 9. Our data confirm that the genetic determination of pyruvate kinase in liver and red cells is separate from that in other tissues. In addition, our results indicate that the muscle (M1) and kidney (M2) pyruvate kinase isozymes share at least one genetic determinant and may in fact be determined by the same structural gene.
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